Air pollution and decreased bone mineral density among Women's Health Initiative participants
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background: Osteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority. Methods: at participants' geocoded addresses (1-, 3-, and 5-year averages before BMD assessments). We measured whole-body, total hip, femoral neck, and lumbar spine BMD at enrollment and follow-up (Y1, Y3, Y6) via dual-energy X-ray absorptiometry. We estimated associations using multivariable linear and linear mixed-effects models and mixture effects using Bayesian kernel machine regression (BKMR) models. Findings: concentration. BKMR suggested that nitrogen oxides exposure was inversely associated with whole-body and lumbar spine BMD. Interpretation: In this cohort study, higher levels of air pollutants were associated with bone damage, particularly on lumbar spine, among postmenopausal women. These findings highlight nitrogen oxides exposure as a leading contributor to bone loss in postmenopausal women, expanding previous findings of air pollution-related bone damage. Funding: US National Institutes of Health.
Source: EClinicalMedicine
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,000
Funders: University of Pennsylvania, Pennsylvania State University, National Institutes of Health, Penn State College of Medicine, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences, National Center for Advancing Translational Sciences
Awards: Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity Risks, A Practical Tool for Managing the Complexity of Biologics Process Manufacturing, Epigenetic Mechanisms of PM-Mediated CVD Risk, Mega-scale Identification tools for xenobiotic metabolism, Air Pollution and Pregnancy Loss, A Practical Tool for Managing the Complexity of Biologics Process Manufacturing, Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort, G571830633, Air Particulate, Metals, and Cognitive Performance in an Aging Cohort- Roles of Circulating Extracellular Vesicles and Non-coding RNAs, Extracellular vesicles in Environmental Epidemiology Studies of Aging, Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health Studies, G6238440229, Stress, Epigenetics and Aging, Principal Component Pursuit to Assess Exposure to Environmental Mixtures in Epidemiologic Studies, G6894818919, Prenatal Exposures to Flame-Retardants: Mitochondrial Signatures and Childhood Obesity, G7348868804, G7821233859, G796413602, G8836210513, Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population-based cohort study, G9000268523, UNC Center for Environmental Health and Susceptibility, Center for Environmental Health in Northern Manhattan
OpenAlex ID: W4320928774