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Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Gaps exist in our understanding of the clinical course of pouch-related disorders. METHODS: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. RESULTS: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. CONCLUSIONS: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.
DOI: 10.1093/crocol/otaa039
Authors: Edward L Barnes, Laura Raffals, Millie D Long, Gaurav Syal, Maia Kayal, Ashwin Ananthakrishnan, Benjamin Cohen, Joel Pekow, Parakkal Deepak, Jean-Frederic Colombel, Hans H Herfarth, Robert S Sandler
Institutions: University of North Carolina at Chapel Hill, Mayo Clinic, Cedars-Sinai Medical Center, Icahn School of Medicine at Mount Sinai, Massachusetts General Hospital, University of Chicago, Washington University in St. Louis
Language: English
Subfield: Genetics
Open Access status: gold
Estimated APC paid: $3,378
OpenAlex ID: W3043953533
FWCI: 1.169
Cites: 37
Cited by: 12
Related to: 10