Work

The multifaceted roles of extracellular vesicles for therapeutic intervention with non-Hodgkin lymphoma

Year: 2024

Type: article

Abstract: Extracellular vesicles (EVs) contribute to the development of cancer in various ways. Non-Hodgkin lymphoma (NHL) is a cancer of mature lymphocytes and the most common hematological malignancy globally. The most common form of NHL, diffuse large B-cell lymphoma (DLBCL), is primarily treated with chemotherapy, autologous stem cell transplantation (ASCT), and/or chimeric antigen receptor T-cell (CAR-T) therapy. With NHL disease progression and its treatment, extracellular vesicles play remarkable roles in influencing outcomes. This finding can be utilized for therapeutic intervention to improve patient outcomes for NHL. This review focuses on the multifaceted roles of EVs with NHL and its potential for guiding patient care.

Source: Extracellular Vesicles and Circulating Nucleic Acids

DOI: 10.20517/evcna.2024.07

Authors: Arthur A. Lee, Andrew K. Godwin, Haitham Abdelhakim

Institutions: University of Kansas, University of Kansas Medical Center, The University of Kansas Cancer Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of General Medical Sciences