Ethylene Oxide Hemoglobin Adducts in Cord Blood and Offspring’s Size at Birth: The NewGeneris European Cohort Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Prenatal ethylene oxide exposure may have adverse effects on fetal development. We examined the relationships between ethylene oxide hemoglobin (Hb) adduct levels and offspring's size at birth in a prospective European mother-child study. METHODS: This study included 1106 singletons from the NewGeneris project (2006-2010) with ethylene oxide Hb adducts measured in cord blood. We examined the relationships between adduct levels and offspring's size at birth among all infants and separately among infants of nonsmokers, using linear regression models for birth weight and birth head circumference and logarithmic binomial regression models for small for gestational age. We examined potential interactions between CYP2E1 single nucleotide polymorphisms in cord blood and the effects of ethylene oxide Hb adduct levels on offspring birth size. RESULTS: Higher quartiles of adduct levels as a measure of exposure were associated with decreasing birth weight and head circumference in the overall population. Compared to infants in the lowest quartile, those in the highest quartile exhibited lower birth weight (-70.73 g, 95% confidence interval = -141.16, -0.30) and reduced head circumference (-0.30 cm, 95% confidence interval = -0.58, -0.02). We observed similar, albeit less pronounced, patterns among infants of nonsmokers. There was no evidence of an association between ethylene oxide Hb adducts and risk of small for gestational age, nor consistent evidence of an interaction with CYP2E1 polymorphisms on the association between EO Hb adduct levels and offspring's size at birth. CONCLUSION: Results suggest that higher ethylene oxide Hb adduct levels in cord blood are associated with a reduction in offspring birth size.
Source: Epidemiology
Authors: Barbara N. Harding, Silvia Agramunt, Marie Pedersen, Lisbeth E. Knudsen, Jeanette K. S. Nielsen, John Wright, Marina Vafeiadi, Domenico F. Merlo, Leslie Stayner, Kaitlin Kelly-Reif, Ana Espinosa, Mariona Bustamante, Kristine Bjerve Gützkow, Berit Granum, Hans von Stedingk, Per Rydberg, Jan Alexander, Margareta Törnqvist, Manolis Kogevinas
Institutions: Universitat Pompeu Fabra, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universitat Autònoma de Barcelona, Hospital Del Mar, University of Copenhagen, Bradford Institute for Health Research, University of Crete, Azienda Sanitaria Unità Locale di Reggio Emilia, University of Illinois Chicago, National Institute for Occupational Safety and Health, Hospital del Mar Research Institute, Norwegian Institute of Public Health, Stockholm University, Karolinska Institutet
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Funders: National Institute for Health and Care Research, European Commission, Svenska Forskningsrådet Formas, Vetenskapsrådet, Ministerio de Ciencia e Innovación, Norges Forskningsråd, Utdannings- og forskningsdepartementet, National Institutes of Health, Centers for Disease Control and Prevention, Instituto de Salud Carlos III, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, H2020 European Research Council
Awards: G1656120899, G1812338929, Effects of Prenatal Exposure to Acrylamide on Health: Prospective Biomarker-Based Studies, G2716889063, Gene-Environment Interactions in an Autism Birth Cohort, G4264544794, G434337789, G5661482178, NORWAY MOTHER AND CHILD COHORT STUDY: CONTINUED SPECIMEN, Development and evaluation of interventions for the prevention of childhood obesity in a multi-ethnic population: the Born in Bradford NHS Research Programme., G7465068618, G8579957264, Acciones Individuales MSCA - Sello de Excelencia ISCIII-HEALTH
OpenAlex ID: W4400068244