Shared vulnerability and sex-dependent polygenic burden in psychotic disorders
Year: 2024
Type: article
Study design: Observational Study
Abstract: Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.
Source: European Neuropsychopharmacology
Authors: Marina Mitjans, Sergi Papiol, Mar Fatjó-Vilas, Javier González-Peñas, Miriam Acosta-Díez, Marina Zafrilla-López, Javier Costas, Celso Arango, Elisabet Vilella, Lourdes Martorell, M Dolores Moltó, Julio Bobes, Benedicto Crespo-Facorro, Ana González-Pinto, Lourdes Fañanás, Araceli Rosa, Bárbara Arias
Institutions: Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, Institut de Recerca Sant Joan de Déu, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Max Planck Institute of Psychiatry, Institut für Psychiatrische Phänomik und Genomik, Ludwig-Maximilians-Universität München, Fidmag Sisters Hospitallers, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria de Santiago, Institut Pere Mata, Institut de Recerca Biomèdica Catalunya Sud, Universitat Rovira i Virgili, Universitat de València, INCLIVA Health Research Institute, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Servicio de Salud del Principado de Asturias, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, University of the Basque Country, Hospital Universitario Araba
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
OpenAlex ID: W4400085904