Work

Selenylation of N‐(P‐Methoxyaryl)Propiolamides via CuBr2 Catalysis: Synthesis of 3‐Selenospiro[4,5]Decatrienones via Ipso‐Cyclization

Year: 2024

Type: article

Abstract: Herein, a method for the assembly of biologically valuable 3‐selenospiro[4,5]decatrienones through CuBr2‐catalyzed ispo‐cyclization of Se powder, boronic acids, and N‐(p‐methoxyaryl)propiolamides has been established. In this protocol, noble transition metal, prefunctionalized selenylation reagent, and strong chemical oxidant are not employed. This method feature wide substrate scope, good functional group tolerance, easy operation, and employing earth‐abundant metal as catalyst and green air as oxidant. Furthermore, several derivatizations of 3‐selenospiro[4,5]decatrienones are performed to showcase the practicability of our strategy.

Source: ChemCatChem

DOI: 10.1002/cctc.202400929

Authors: Jinhui Cai, Kaili Cen, Hongyi Lin, Haixia Zhang, Nannan Zhou, Qiaolin Wang

Institutions: University of South China, Chuanshan College University of South China

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hunan Province

Awards: G1486668146, G7367184900