Work

Thyroid Hormone Status in Mice Lacking Selenium Recycling

Year: 2024

Type: article

Abstract: Objectives: Selenium (Se) recycling in cells is carried out by the enzyme selenocysteine (Sec) lyase (Scly), which decomposes the amino acid Sec to provide Se back to selenoprotein synthesis. Mice without Scly (Scly KO) reduce their thermogenic capacity in the brown adipose tissue (BAT), leading to obesity. Thermogenesis is critically regulated by thyroid hormone (TH) status and activation by the enzyme type 2 deiodinase (Dio2) in brown adipocytes (BA). Thus, our objective is to evaluate circulating TH levels and activation in Scly KO mice and mice lacking Scly in BA only (BA-Scly KO).

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2024.103721

Authors: Lucia A Seale, Princess J Santiago, Naghum Alfulaij, Sydonie Swanson, Pamela Toh, Briana K Shimada

Institutions: University of Hawaiʻi at Mānoa, University of Hawaii System, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Selenium in Biological Systems

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000