Early Weight Loss and Other Predictors of Clinically Significant Weight Loss on Two Commercial Weight Loss Programs
Year: 2024
Type: article
Abstract: levels involved in inflammation and permeability were measured by RT-qPCR.Results: Vitamin D supplementation improved HFD-induced adipose tissue mass without changing body weight and food intake.However, circulating levels of proinflammatory cytokines such as NO and TNF-α were significantly decreased by vitamin D supplementation in HFD-fed obese mice.Additionally, vitamin D supplementation significantly decreased mRNA levels IL-6, MCP-1, and TNF-α related to inflammation in colon from obese mice.Occluding and zo-1 gene expression involved in permeability was suppressed by vitamin D supplementation in accompanied with the increment of AMPK activity in the colon.Conclusions: This study indicates that intestinal inflammation in obese mice was reversed by vitamin D supplementation in HFD-fed obese mice in accompanied with increased gene expression related to permeability and AMPK activity.It suggests the favorable effects of vitamin D on obesity-induced intestinal inflammation along with the improvement of intestinal permeability.
Authors: Christopher Coleman, Jessica R Kiel, Orsolya M Palacios, Marjorie Bell, Meredith L Wilcox, Kevin C Maki, Jessica L Unick, Satya S Jonnalagadda
Institutions: Medifast, Inc. (United States), Brown University
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,000
OpenAlex ID: W4400148341