Work

Is Fucoxanthin a Potential Regulator of the Mitochondrial Permeability Transition Pore?

Year: 2024

Type: article

Abstract: Objectives: Excitotoxicity is a condition that is observed during brain disorders such as cerebral ischemia and is a result of an excessive release of glutamate in the brain. During excitotoxicity, cytosolic calcium overload triggers the opening of the mitochondrial permeability transition pore (mPTP), which disrupts the integrity of the mitochondrial membrane and causes energy depletion, ultimately leading to neuronal death. Fucoxanthin is a carotenoid found in brown seaweed that protects the brain against the pathology associated with mitochondrial dysfunction.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2024.103191

Authors: Khondoker Adeba Ferdous, Rebecca Bloch, Kristi M Crowe-White, Amy C Ellis, Han-A Park

Institution: University of Alabama

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000