Work

Effect of High-Fat Diet-Induced Obesity on the Metabolism of (-)-Epigallocatechin-3-Gallate at Non-Toxic and Toxic Doses in Mice

Year: 2024

Type: article

Abstract: Objectives: With the rising prevalence of obesity, green tea-based dietary supplements have gained popularity due to their potential to mitigate obesity. However, studies have reported that oral bolus doses of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, have the potential to induce hepatotoxicity. The underlying mechanism of the toxicity is unclear, but it has been reported that changes in EGCG metabolite profile may contribute to the toxicity. Given that obesity can affect the activity of phase Ⅱ enzymes, obesity may alter EGCG metabolism and toxicity.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2024.102630

Authors: Soomee Hwang, Imhoi Koo, Andrew D Patterson, Joshua D Lambert

Institution: Pennsylvania State University

Language: English

Topic: Tea Polyphenols and Effects

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000