Editor's evaluation: The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus
Year: 2023
Type: peer-review
Abstract: Interferon contributes to photosensitivity at least in part by causing Langerhans cell ADAM17 dysfunction, raising the possibility that anifrolumab ameliorates lupus skin disease in part by restoring Langerhans cell function.
Source: eLife
Author: Detlef Weigel
Institution: Max Planck Institute for Biology
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: U.S. Department of Defense, St. Giles Foundation, Alpha Omega Alpha Honor Medical Society, Lupus Research Alliance, Hospital for Special Surgery, Tow Foundation, Austrian Science Fund, National Institutes of Health, Weill Cornell Medical College, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: Defining T helper cell associated cytokines and mechanisms in Alopecia Areata, G3376477779, G3865632432, G4119534169, G5850682332, Skin-lymph node axis in SLE, Role of iRhoms and ADAM17 in EGFR and TNFalpha signaling, Cell Sorter, Weill Cornell/Rockefeller/Sloan Kettering MST Program, Lymphatic regulation of lymph node function in lupus, Glucocorticoid-regulated transcription networks in macrophage biology, IL-27 and downstream mechanisms in Alopecia Areata, HSS Research Institute Rheumatology Training
OpenAlex ID: W4400195950