Year: 2024
Type: review
Abstract: INTRODUCTION: Understanding the interactions between administered nanoparticles and the liver is crucial for developing safe and effective nanomedicines. As the liver can sequester up to 99% of these particles due to its major phagocytic role, understanding these interactions is vital for clinical translation. AREAS COVERED: This review highlights recent studies on nanoparticle-liver interactions, including the influence of nanoparticle physicochemical properties on delivery, strategies to enhance delivery efficiency by modulating liver Kupffer cells, and their potential for treating certain hepatic diseases. Additionally, we discuss how aging impacts the liver's phagocytic functions. EXPERT OPINION: While liver accumulation can hinder nanomedicine safety and effectiveness, it also presents opportunities for treating certain liver diseases. A thorough understanding of nanoparticle-liver interactions is essential for advancing the clinical application of nanomedicines.
Source: Expert Opinion on Drug Delivery
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: G2764737419, Engineering a novel surface coating platform for nanomedicines, CAREER: Understanding Nanoscale Interactions at Single-Particle and Single-Cell Levels, G3886809164, A novel framework for nanomedicine development, G6671297155, G9000271663, Oklahoma Center of Medical Imaging for Translational Cancer Research
OpenAlex ID: W4400212111