Work

Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment

Year: 2024

Type: article

Abstract: • scRNA seq is a advanced technology to dissect the immune microenvironment of SO induced long-term pulmonary toxicity. • cDC, ILCs and monocytes activation may play crucial roles in SO-induced pulmonary toxicity. • CCL3 signal released by ILCs may activate the inflammatory cascade of monocytes in lung tissues of SO-treated rats. • VEGF activated in monocytes highly participated in the inflammatory cascade caused by SO.

Source: Journal of Pharmaceutical Analysis

DOI: 10.1016/j.jpha.2024.101035

Authors: Fan Zhang, Shu Gan, Jingjing Liao, Ting Jiang, Zhiqiang Shi, Xueying Fan, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su

Institutions: Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Hong Kong Baptist University, Macau University of Science and Technology

Language: English

Topic: Immunotoxicology and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850

Funders: Guangdong Provincial Hospital of Traditional Chinese Medicine, Administration of Traditional Chinese Medicine of Jilin Province, National Natural Science Foundation of China, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1226781796, G190944839, G7668404394, G7799215577, G8698416158, G8911606432

OpenAlex ID: W4400230526

FWCI:

Cites: 5

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Related to: 10