Year: 2024
Type: article
Abstract: Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric restriction can extend fly life is not clear. Here we show that late-life calorie restriction increases lifespan in female Drosophila melanogaster aged on a high-calorie diet. This shift results in rapid decrease in mortality rate and extends fly lifespan. In contrast, shifting female flies from a low- to a high-calorie diet leads to a rapid increase in mortality and shorter lifespan. These changes are mediated by immediate metabolic and physiological adaptations. One of such adaptation is rapid adjustment in egg production, with flies directing excess energy towards egg production when shifted to a high diet, or away from reproduction in females shifted to low-caloric diet. However, lifelong female fecundity reveals no associated fitness cost due to CR when flies are shifted to a high-calorie diet. In view of high conservation of the beneficial effects of CR on physiology and lifespan in a wide variety of organisms, including humans, our findings could provide valuable insight into CR applications that could provide health benefits later in life.
Source: GeroScience
Authors: Michael Li, Jacob Macro, Billy J. Huggins, Kali Meadows, Dushyant Mishra, Dominique Martin, Kavitha Kannan, Blanka Rogina
Institution: UConn Health
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,190
Awards: Non-Autonomous control of aging in Drosophila, Calorie Restriction and Hallmarks of Aging in Drosophila, G328804621, G3839909718, The UConn/JAX-GM Training Program in Genomic Science, G6950492127, Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional), Training Grant In Tumor Biology
OpenAlex ID: W4400254348