Environmental circadian disruption re-writes liver circadian proteomes
Year: 2024
Type: article
Abstract: Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the rhythmicity of 64% transcriptome, 98% whole-cell proteome and 95% nuclear proteome. The re-writing, which is associated with changes of circadian regulatory cis-elements, RNA-processing and protein localization, diminishes circadian regulation of fat and carbohydrate metabolism and persists after one week of ECD-recovery.
Source: Nature Communications
Institution: Morehouse School of Medicine
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,790
Awards: G1926888765, G2543901735, The retinal clock modulates cell viability, retinal circuitry and locomotor activity rhythm, Visualizing hierarchical processing of photic input to the circadian clock in vivo, Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center, Melatonin Signaling in Photoreceptors, Circadian regulation of RPE functions, Defining the role of sleep in resilience to social stress, Role of sex and protein degradation in the circadian clock, Center for Translational Research in Health Disparities, Potential Role of Compass H3K4 Methyltransferase Complexes in Environmental Circadian-Alignment
OpenAlex ID: W4400260909