Figure 2 from The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors
Year: 2024
Type: other
Abstract: Spatial genomics uncovers hotspots of transcriptomic changes associated with glucocorticoid receptor signaling. A, Visualization of spatial gene expression of key genes correlated with the neighborhood violent crime rate in representative tumor samples from high and low-violence neighborhoods. Spatial expression was visualized in Seurat. B, Hot spot analysis of key genes correlated with the violent crime rate in representative tumor samples from high and low-violence neighborhoods. Hotspots were identified using the univariate local Moran’s test. Darker colors denote a P-value of <0.01 and lighter colors indicate a P-value of <0.05. C, Pathway analysis of genes differentially expressed within P < 0.01 highest expression within the sample hotspots. Differential gene expression analysis was performed using FindMarkers in Seurat, and genes with a non-adjusted P-value of <0.05 were used for pathway analysis. Analysis of pathways with a P-value of <0.05 was performed in DAVID using Biocarta, Kegg, and Wikipathways analysis.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4400283282