Figure 1 from The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors
Year: 2024
Type: other
Abstract: Gene expression programs and neighborhood violent crime rates in lung tumors. A, Heatmap of genes correlated with violent crime rates per 1,000 (P < 0.05). Average normalized gene expressions per tumor sample were extracted from spatial transcriptomics data and checked for correlation with violent crime per 1,000. Housekeeping genes were removed and data were log-transformed and hierarchically clustered prior to visualization. From (left to right), samples are ordered from lowest violent crime ranking to highest violent crime ranking. B, Heatmap of genes correlated with overall crime rates (P < 0.05). Average normalized gene expressions per sample were extracted from spatial transcriptomics data and checked for correlation with violent crime per 1,000. Housekeeping genes were removed and data was log-transformed and hierarchically clustered prior to visualization. From (left to right), samples are ordered from lowest violent crime ranking to highest violent crime ranking. C, Pathway analysis of genes upregulated with violent crime rates per 1,000 (P < 0.05). Upregulated genes were extracted from the violent crime heatmap, and functional annotation of genes was performed in DAVID using Biocarta, Kegg, and Wikipathways analysis. D, Pathway analysis of genes upregulated with overall crime (P < 0.05). Upregulated genes were extracted from the violent crime heatmap, and functional annotation of genes was performed in DAVID using Biocarta, Kegg, and Wikipathways analysis. Abbreviation. T, tumor.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4400283508