Work

Research on the genetic etiology of polycystic ovary syndrome in the post-GWAS era

Year: 2024

Type: article

Abstract: Great progress has been made in the genetic research of PCOS, thanks to the application of genome association study (GWAS) technology. However, in the post-GWAS era, investigating the pathogenic mechanisms related to numerous genetic loci has become challenging, leading to the current generalized approach to treating PCOS. To address this issue, taking the significantly associated susceptibility gene THADA as an example, we share a series of advancements from the perspectives of genetic evolution, epigenetics, and gene function studies. Our aim is to provide guidance for a better understanding of the essence of PCOS.

Source: Global Reproductive Health

DOI: 10.1097/grh.0000000000000086

Authors: Shigang Zhao, Han Zhao, Zi-Jiang Chen

Institutions: Shandong University, State Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University, Renji Hospital

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4400284583

FWCI:

Cites: 5

Cited by:

Related to: 10