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Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo (Adv. Sci. 25/2024)

Year: 2024

Type: article

Abstract: CRISPR/Cas9 Gene Editing Technology Corneal neovascularization (CNV) is a common clinical finding observed in various eye diseases, which can lead to blindness. In article number 2401710, Hetian Lei, Xingtao Zhou, Jinhai Huang, and their colleagues demonstrate the use of CRISPR/Cas9 gene editing technology with selected sgRNA to regulate VEGFA gene expression, and achieving therapeutic purposes. This study establishes a solid foundation for treating CNV through a gene editing approach for the first time.

Source: Advanced Science

DOI: 10.1002/advs.202470145

Authors: Zhenhai Zeng, Siheng Li, Xiuhong Ye, Yiran Wang, Qinmei Wang, Zhongxing Chen, Ziqian Wang, Jun Zhang, Qing Wang, Lu Chen, Shuangzhe Zhang, Zhilin Zou, Meimin Lin, Xinyi Chen, Guoli Zhao, Colm McAlinden, Hetian Lei, Xingtao Zhou, Jinhai Huang

Language: English

Topic: Corneal Surgery and Treatments

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,120

OpenAlex ID: W4400291784

FWCI:

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