Work

Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization

Year: 2026

Type: article

Source: Nature Cardiovascular Research

DOI: 10.1038/s44161-025-00762-7

Authors: Junichi Saito, Jui M. Dave, Eunate Gallardo-Vara, Nandhini Sadagopan, Inamul Kabir, George Tellides, Robert K. Riemer, Zsolt Urban, Sarah Spiegel, Timothy Hla, Daniel M. Greif

Institutions: Yale University, Stanford Medicine, Stanford University, University of Pittsburgh, Virginia Commonwealth University, Boston Children's Hospital, Harvard University

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, Japan Society for the Promotion of Science, National Institute on Aging, National Heart, Lung, and Blood Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G3907600513, Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularization, Pathological arterial muscularization and the role of integrins, G6685406427, Role of sphingosine kinase 1 in supravalvular aortic stenosis, Intrinsic and non-cell autonomous regulation of the SMC epigenetic clock, Mechanisms of reverse vascular remodeling in pulmonary hypertension, Novel vascular smooth muscle cell progenitors in development and disease, Sphingolipid signaling in age-associated vascular pathology, Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularization, Epigenetic-mediated Notch pathway activation promotes elastin aortopathy

OpenAlex ID: W7118176552

FWCI: 4.087

Cites: 83

Cited by: 2

Related to: 10