Figure 1 from Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis
Year: 2024
Type: other
Abstract: Secretome of human breast cancer cells modulates adipogenesis. A, Schematic of experimental workflow. Breast cancer cell secretomes were added only during the first 2 days of 3T3-L1 adipogenesis. B, Effect of human breast cancer cell line secretomes on 3T3-L1 adipogenesis. C and D, The secretome of TNBC cell lines MDA-MB-468 and MDA-MB-231 inhibits the differentiation of primary murine ASPCs as assessed by (C) lipid accumulation during adipogenesis and (D) expression of adipogenic genes Pparγ, Cebpα, and Adipoq. B–D, All data are mean ± SD. Data points show independent biological replicates. P values calculated using (B and D) one-way ANOVA followed by Dunnett’s multiple comparison test or (C) two-way ANOVA followed by Šidák’s multiple comparison test. (**, P < 0.01; ***, P < 0.001; ****, P < 0.0001; A, Created with BioRender.com.)
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4400345383