Work

Unveiling Cellular Identities and Gene Expression Pathways in Overlapping Myocarditis and Myositis

Year: 2024

Type: article

Abstract: Immune checkpoint therapies can drive antitumor responses and benefit patients but can also induce life-threatening immune-related adverse events such as myocarditis and myositis. These immune-related adverse events are rare but carry substantial morbidity and mortality. In this issue, Siddiqui and colleagues use single-cell RNA and T-cell receptor sequencing to identify novel cellular subsets and propose various mechanisms that could contribute to the pathogenesis of immune checkpoint inhibitor-associated myocarditis and myositis. These new insights should help move the field toward the development of improved treatment and prevention options, ultimately improving patient outcomes. See related article by Siddiqui et al., p. 964 (1).

Source: Cancer Immunology Research

DOI: 10.1158/2326-6066.cir-24-0506

Authors: Reilly G. Fankhauser, Douglas B. Johnson, Javid J. Moslehi, Justin M. Balko

Institutions: Vanderbilt University Medical Center, University of California, San Francisco, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences