Work

Incidental melanoma and thyroid cancer lead to diagnosis of Lynch syndrome and endometrial cancer: A case report

Year: 2024

Type: article

Abstract: Hereditary nonpolyposis colorectal cancer, or Lynch syndrome, is an autosomal dominant cancer predisposition syndrome caused by pathogenic germline variants in DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, PMS1 homolog 2 [PMS2]) or deletions in epithelial cell adhesion molecule.1,2 Lynch syndrome is most clearly associated with increased risk of colorectal and endometrial cancers, as well as skin cancers including sebaceous neoplasms and keratoacanthoma-type squamous cell carcinoma.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2024.06.023

Authors: Molly E. Kuo, Emily H. Smith, Jaclyn Plotzke, May Chan, Tobias Else, Kelly B. Cha

Institutions: University of Michigan, Saint Louis University, Michigan Medicine

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750