Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction
Year: 2024
Type: article
Abstract: Glutamine metabolism is altered in both infarct macrophages and the remote left ventricle (LV) following myocardial infarction (MI). Supplemental glutamine improves LV function following MI while inhibiting glutamine metabolism with BPTES worsens LV function. Supplemental glutamine or BPTES does not impact macrophage immunometabolic phenotypes after MI.
Authors: Alan J. Mouton, Nikaela M. Aitken, Jemylle G. Morato, Katherine R. O’Quinn, Jussara M. do Carmo, Alexandre A. da Silva, Ana C. M. Omoto, Xuan Li, Zhen Wang, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Joshua K. Stanford, Jordan A. Brown, John E. Hall
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1276576940, G1422855837, G182294559, G1865087954, G2281790343, G3145357611, G4007359537, G4783045689, G5443733967, G5681031414, Cardiorenal and Metabolic Diseases Research Center, Cardiac protection by CNS actions of leptin administration after ischemia/reperfusion, Role of Macrophage Metabolism in Myocardial Ischemic Injury, Long-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspring, Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction, Mississippi Center for Clinical and Translational Research
OpenAlex ID: W4400438528