The role of reactive oxygen species in gastric cancer
Year: 2024
Type: article
Abstract: Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.
Source: Cancer Biology and Medicine
Authors: Yuqi Wang, Jingli Xu, Zhenjie Fu, Ruolan Zhang, Weiwei Zhu, Qianyu Zhao, Ping Wang, Can Hu, Xiangdong Cheng
Institutions: Zhejiang Cancer Hospital, Zhejiang University of Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,500
Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, National Key Research and Development Program of China, Medical Science and Technology Project of Zhejiang Province, Natural Science Foundation of Zhejiang Province, Science and Technology Program of Zhejiang Province
OpenAlex ID: W4400458001