Figure 3 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Year: 2024
Type: other
Abstract: The presence of certain microbes in ORIEN tumors correlates with worse outcomes after radiotherapy. A, List of strains whose interactions with hypoxia in the tumor are significantly associated with survival outcomes in ORIEN patients who received radiation treatment. B, Kaplan–Meier survival curve showing an association between the presence of F. canifelinum and patient outcome. A risk table for this result is available as Supplementary Table S6. C, Model CT26 tumors grown in immune-deficient mice and inoculated with Fusobacterium show no increase in tumor growth delay after radiotherapy. D, Similarly, model tumors inoculated with several other bacterial strains show significant increases in tumor growth delay after radiotherapy. The strains included are Lactobacillus (Lacto), a mixed population from a healthy donor (Gut Mix), bacterial growth medium (GAM), Streptococcus (Strepto), and Akkermansia (AKK). Error bars are ±SEM. P values were calculated against GAM using the t test. *, P < 0.05.
Authors: Martin Benej, Rebecca Hoyd, McKenzie Kreamer, Caroline E. Wheeler, Dennis J. Grencewicz, Fouad Choueiry, Carlos H.F. Chan, Yousef Zakharia, Qin Ma, Rebecca D. Dodd, Cornelia M. Ulrich, Sheetal Hardikar, Michelle L. Churchman, Ahmad A. Tarhini, Lary A. Robinson, Eric A. Singer, Alexandra P. Ikeguchi, Martin D. McCarter, Gabriel Tinoco, Marium Husain, Ning Jin, Aik C. Tan, Afaf E.G. Osman, Islam Eljilany, Gregory Riedlinger, Bryan P. Schneider, Katarina Benejova, Martin Kery, Ioanna Papandreou, Jiangjiang Zhu, Nicholas Denko, Daniel Spakowicz
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4400499239