Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age
Year: 2024
Type: article
Study design: Observational Study
Abstract: The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.
Source: Nature Communications
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,790
Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Institute on Deafness and Other Communication Disorders, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G2206284347, Institutional Career Development Core, G2474698835, G3612564990, Neurobehavioral Research on Infants at Risk for Language Delay and ASD, Molecular mechanisms of aging in the intrinsic laryngeal muscles, G4529922095, G5299719280, G5388462274, Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum Disorder, G58798366, G6341965972, Clinical and Translational Science Award, G7235420978, G7412978817, G8953153783, Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center, Translational Post-doctoral Training in Neurodevelopment, Analgesic-Behavioral and Neurophysiological Correlates of Opioid-Sparing Spinal Anesthesia Compared to General Anesthesia in Human Infants, Neural, Physiological, Behavioral, and Environmental Risk Markers of Anxiety from Infancy to Adolescence
OpenAlex ID: W4400499302