Figure 1 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Year: 2024
Type: other
Abstract: Hypoxia exists in colorectal cancer and predicts poor patient outcomes after X-ray therapy. A, Hypoxia expression signature scores for the ORIEN dataset across tumor sites showing a wide distribution for COAD and READ samples. The median values are indicated with a black circle. Abbreviated cancer names are lung squamous cell carcinoma (LUSC), skin cutaneous melanoma (SKCM), small cell lung cancer (SCLC), lung adenocarcinoma (LUAD), sarcoma (SARC), pancreatic adenocarcinoma (PAAD), other colorectal cancers (Other CR), and thyroid carcinoma (THCA). B, A comparison of the Buffa score histogram of ORIEN with TCGA colorectal cancer datasets shows a similar mode in both but with a wider distribution for ORIEN. Tertiles used to designate “high” and “low” hypoxia are marked with dashed lines. C, Comparison of Buffa scores in normal adjacent and normal GTEx data compared with colon and rectal cancers (TCGA). D, For ORIEN patients receiving radiotherapy, a Kaplan–Meier curve stratifying the patient population into upper and lower hypoxia tertiles shows that hypoxic tumors have a worse patient outcome. E, Cox proportional hazard P values calculated by stratifying the hypoxia scores at every percentile (x-axis). The larger area above the horizontal dotted line indicates the strong separation of survival at a range of threshold values and is therefore more robust than single threshold analyses for small sample sizes. The total area of the Buffa hypoxia score was slightly larger than the others (inset).
Authors: Martin Benej, Rebecca Hoyd, McKenzie Kreamer, Caroline E. Wheeler, Dennis J. Grencewicz, Fouad Choueiry, Carlos H.F. Chan, Yousef Zakharia, Qin Ma, Rebecca D. Dodd, Cornelia M. Ulrich, Sheetal Hardikar, Michelle L. Churchman, Ahmad A. Tarhini, Lary A. Robinson, Eric A. Singer, Alexandra P. Ikeguchi, Martin D. McCarter, Gabriel Tinoco, Marium Husain, Ning Jin, Aik C. Tan, Afaf E.G. Osman, Islam Eljilany, Gregory Riedlinger, Bryan P. Schneider, Katarina Benejova, Martin Kery, Ioanna Papandreou, Jiangjiang Zhu, Nicholas Denko, Daniel Spakowicz
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4400499571