Persistent organic pollutants and cognitive decline among middle-aged or older adults in the Hispanic Community Health Study/Study of Latinos
Year: 2024
Type: article
Study design: Observational Study
Abstract: Persistent organic pollutants may negatively impact cognition; however, associations between persistent organic pollutants and changes in cognition among United States Hispanic/Latino adults have not been investigated. Herein, we examined the associations between 33 persistent organic pollutants and cognitive changes among 1837 Hispanic/Latino adults. At baseline (2008-2011; Visit 1), participants provided biospecimens in which we measured levels of 5 persistent pesticides or pesticide metabolites, 4 polybrominated diphenyl ethers and 2,2',4,4',5,5'-hexabromobiphenyl, and 24 polychlorinated biphenyls. At Visit 1 and again at Visit 2 (2015-2018), a battery of neurocognitive tests was administered which included the Brief-Spanish English Verbal Learning Test, Word Fluency Test, and Digit Symbol Substitution Test. To estimate the adjusted associations between changes in cognition and each POP, we used linear regression for survey data. Each doubling in plasma levels of polychlorinated biphenyls 146, 178, 194, 199/206, and 209 was associated with steeper declines in global cognition (βs range:-0.053 to -0.061) with stronger associations for the Brief-Spanish English Verbal Learning Test. Persistent organic pollutants, in particular polychlorinated biphenyls, were associated with declines in cognition over 7 years and may be a concern for Hispanic/Latino adults.
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,990
Funders: U.S. Department of Health and Human Services, Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, Centers for Disease Control and Prevention, Albert Einstein College of Medicine, Yeshiva University, University of North Carolina at Chapel Hill, University of California, San Diego, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1075639496, G1081972346, Persistent Organic Pollutants, Endogenous Hormones and Diabetes in Latinos, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1587824183, G1666450717, G1917633662, G2135211244, G2135293100, G213973861, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G269438424, G2970637568, G3062787641, Hispanic Community Health Study, G3677686024, G3722034730, G3838006641, G3952816605, Study of Latinos Investigation of Neurocognitive Aging 2, G4121762840, Hispanic Community Health Study, G4552920371, G4860668542, G4989378220, G528357465, G5365244667, G543802643, G5517444337, G5545397803, G555858244, G5739677117, G5878028785, G5906656038, G6075306088, G6156511736, G6585687856, G6744188800, G6840272165, G7057037114, G718473075, G7203655167, G7239480477, G7272721675, G7278742613, G7400840618, G7408420985, G7513901258, G7678550560, G8102260223, Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) Study, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, G9000332211, 1/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease, ChicAgo Center for Health and EnvironmenT (CACHET), 2/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership, San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR), UCSD Integrated Cardiovascular Epidemiology Fellowship
OpenAlex ID: W4400603330