Work

NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance

Year: 2024

Type: article

Abstract: Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation therapy, chemotherapy, and immunotherapy. See related article by Teijeira et al., p. 4131.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-24-1363

Authors: Yvonne M. Mowery, Jason J. Luke

Institutions: University of Pittsburgh, Duke University, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Damon Runyon Cancer Research Foundation, National Institutes of Health, National Cancer Institute, National Institute of Dental and Craniofacial Research