The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder
Year: 2024
Type: article
Study design: Observational Study
Abstract: Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD); however, the pattern of family history and genetic overlap among them requires clarification. This study investigated the diagnostic, familial, and genetic associations of EDs with ADHD and ASD. The nationwide population-based cohort study included all individuals born in Denmark, 1981-2008, linked to their siblings and cousins. Cox regression was used to estimate associations between EDs and ADHD or ASD, and mediation analysis was used to assess the effects of intermediate mood or anxiety disorders. Polygenic scores (PGSs) were used to investigate the genetic association between anorexia nervosa (AN) and ADHD or ASD. Significantly increased risk for any ED was observed following an ADHD or ASD diagnosis. Mediation analysis suggested that intermediate mood or anxiety disorders could account for 44%-100% of the association between ADHD or ASD and ED. Individuals with a full sibling or maternal half sibling with ASD had increased risk of AN compared to those with siblings without ASD. A positive association was found between ASD-PGS and AN risk whereas a negative association was found between AN-PGS and ADHD. In this study, positive phenotypic associations between EDs and ADHD or ASD, mediation by mood or anxiety disorder, and genetic associations between ASD-PGS and AN and between AN-PGS and ADHD were observed. These findings could guide future research in the development of new treatments that can mitigate the development of EDs among individuals with ADHD or ASD.
Source: Molecular Psychiatry
Authors: Gitte Bundgaard Christiansen, Liselotte Vogdrup Petersen, Hannah Chatwin, Zeynep Yilmaz, Diana Schendel, Cynthia M. Bulik, Jakob Grove, Isabell Brikell, Birgitte Dige Semark, Katrine Holde, Mohamed Abdulkadir, Christopher Hübel, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Anders D. Børglum, Ditte Demontis, Preben Bo Mortensen, Janne Tidselbak Larsen
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $5,290
Funders: U.S. Department of Health and Human Services, Klarman Family Foundation, Aarhus Universitet, European Commission, National Research Foundation, Danmarks Grundforskningsfond, Svenska Forskningsrådet Formas, Lundbeckfonden, Novo Nordisk, Vetenskapsrådet, Danmarks Frie Forskningsfond, Novo Nordisk Fonden, H. Lundbeck A/S, National Institutes of Health, Horizon 2020 Framework Programme, Danish Agency for Science and Higher Education, National Institute of Mental Health
Awards: G103800658, G1144900190, G1181994271, 5/7 Psychiatric Genomics Consortium: Finding actionable variation, G1375331873, G1482489452, G1571331078, G1604432842, Eating Disorders Genetics Initiative (EDGI), G211885902, G214445032, G2332261527, G2417586468, G2719215791, G2953470886, G303339423, G3197369316, Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients, G3246699782, G3298186876, G3747547992, G3964009410, G3978918829, G3987400284, G4034426326, G434337789, Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems Approach, G4670273794, G4772171027, G5012122282, G5197328387, G5211151649, Genetic Architecture of Avoidant/Restrictive Food Intake Disorder, G5408826359, G5723885119, G6436024939, G6454032723, G6742998398, G6823670667, G712881263, G72353583, G7554036688, Predicting the multi-omic impact of psychiatric GWAS associations, G8079214437, G8285926421, G873707698, 1/3 Eating Disorders Genetics Initiative 2 (EDGI2), 1/7 PGC: Advancing Discovery and Impact, 2/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact
OpenAlex ID: W4404349486