Work

Geometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Iron oxide nanoparticles (IONPs) are recognized for their potential in biomedical applications due to their distinctive physicochemical properties. This study investigates the synthesis of IONPs with various geometric morphologies─cubic, star-like, truncated icosahedron, and spherical─via thermal decomposition to enhance their utility in magnetic resonance imaging (MRI) and targeted drug delivery. X-ray diffraction analysis verified the Fe 3 O 4 phase in all nanoparticles, illustrating the synthesis’s efficacy. Particle morphologies were well-defined, with sizes ranging from 10 to 150 nm, as determined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Magnetic evaluations using a vibrating sample magnetometer (VSM-PPMs) demonstrated their superparamagnetic behavior, with larger particles exhibiting greater saturation magnetization. Notably, truncated icosahedron and cubic IONPs showed superior transverse relaxation rates, with r 2 values of 56.77 s 1 mM 1 and 42.67 s 1 mM 1, respectively. These results highlight the potential of customizing IONP geometries to optimize their magnetic properties and increase surface area available for functionalization, thereby improving their efficacy for biomedical applications.

Source: ACS Omega

DOI: 10.1021/acsomega.4c03988