Year: 2024
Type: preprint
Abstract: We report the use of a strongly electrophilic thiyl radical derived from commercially available pentafluorothiophenol as a demonstration of highly chemoselective H-atom abstraction from electron-rich, and relatively weak benzylic C-H bonds adja-cent to O- and N-atoms. This approach enables the selective oxidative removal of benzyl and p-methoxybenzyl groups from amines and alcohols under ambient aerobic conditions.
Source: ChemRxiv
Authors: Samuel Lardy, Victoria Lerda, Valerie Schmidt
Institution: University of California San Diego
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4400788615