Work

Drugs need to be formulated with scale-up in mind

Year: 2024

Type: article

Abstract: Formulation scale-up remains a major hurdle in drug development in part because preliminary formulation research efforts rarely consider the challenges of scaling up production for commercialization. This Perspective outlines considerations around scalability that can be incorporated into formulation design work in order to increase the chances of successful translation. Both technical (unit operations, excipient selection, scaling principles) and non-technical (funding, publications, and personnel) considerations are discussed, with a focus on lab-scale work by academic researchers.

Source: Journal of Controlled Release

DOI: 10.1016/j.jconrel.2024.07.016

Author: Kurt D. Ristroph

Institution: Purdue University West Lafayette

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,540

Funder: Purdue University