Work

Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation

Year: 2024

Type: article

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.4c00211

Authors: Carmela Molinaro, Nicholas Wong, Nicholas A. White, Lauren E. Sirois, Raphael Bigler, Quentin P. Bindschaedler, Steven Do, Sushant Malhotra, Francis Gosselin

Institutions: Genentech, F. Hoffmann-La Roche AG

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: closed

OpenAlex ID: W4400881506

FWCI: 0.29

Cites: 71

Cited by: 2

Related to: 10