Year: 2024
Type: editorial
Abstract: RecommendationsV isualizing the three-dimensional binding modes of potential drug molecules within their target sites has significantly impacted the drug discovery paradigm. 1As such, "structurally enabled" drug development campaigns are naturally accelerated.Structural information provides a roadmap for designing molecules that enhance target profile parameters while avoiding alterations that may compromise binding.Development campaigns are also initiated with structural methods by identifying hit molecules (e.g., fragment-based drug discovery and "SAR by NMR") 2,3 and increasingly prevalent computer-aided in silico high-throughput docking screens. 4,5At its core, structural biology provides valuable knowledge about the structural basis of drug function, the activation mechanism of specific targets in disease contexts, and protein-protein interactions underpinning antibody recognition or emerging therapeutic modalities such as molecular glues and PROTAC degraders. 6-8 This Virtual Special Issue aims to highlight the substantial impact of structural biology on therapeutic development as a key component of the medicinal chemistry team sport.At the Journal of Medicinal Chemistry, we invite submissions of Articles, Drug Annotations, and Perspectives.ACS Medicinal Chemistry Letters welcomes Viewpoints, Letters, Notes, Technical Notes, and Microperspectives.These manuscripts should come from academic groups, not-for-profit organizations, and industry on research with a particular emphasis on structural findings that drive drug development.Our goal is to underscore the various ways in which structural biology provides the launching pad for novel therapies, accelerates the optimization of lead compounds, or provides a key structural basis for understanding drug function in vivo and/or in clinical settings.By submitting your work to this Virtual
Source: ACS Medicinal Chemistry Letters
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4400884754