Work

General and Versatile Synthesis of Highly Functionalized BINOL Derivatives and Their Applications in the Synthesis of Recyclable Chiral Phosphoric Acids

Year: 2024

Type: preprint

Abstract: The development of recyclable catalysts has gained more attention in recent years in order to minimize the environmental effect and the overall cost of catalytic processes. Some of the most broadly used chiral organocatalysts are BINOL-derived chiral phosphoric acids, making it necessary to develop efficient recycling strategies. While literature reports require up to 13 synthetic steps to access recyclable chiral phosphoric acids, here we report a general and concise 9-step approach to anthracene decorated heterogeneous chiral phosphoric acids (PS-Anth), which have shown high performance either in batch or continuous flow without observing catalyst degradation.

Source: ChemRxiv

DOI: 10.26434/chemrxiv-2024-nqkmn

Authors: Aitor Maestro, Sándor Ötvös, Gerald Auer, Oliver Kappe

Institutions: University of Graz, University of the Basque Country, Research Center Pharmaceutical Engineering (Austria)

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funders: TU Graz, Internationale Beziehungen und Mobilitätsprogramme, Austrian Science Fund, Eusko Jaurlaritza