Work

Dementia with Lewy bodies can be well‐differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity—[11C]MP4A PET study

Year: 2016

Type: letter

Abstract: Shimada et al. investigated the potential diagnostic utility of brain acetylcholinesterase (AChE) activity measurement using N-[ 11 C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) (Shimada et al., 2015).These investigators found greater reductions in cortical AChE hydrolysis rates in DLB compared to AD subjects.Regional differences in defined volumes-of-interest (VOIs) were significantly lower in DLB compared to AD in all but the anterior cingulate gyrus.By contrast, the largest regional difference between DLB and AD subjects was in the posterior cingulate

Source: International Journal of Geriatric Psychiatry

DOI: 10.1002/gps.4373

Authors: Nicolaas I. Bohnen, Martijn L. T. M. Müller, Daniel I. Kaufer

Institutions: University of Michigan, VA Ann Arbor Healthcare System, University of North Carolina at Chapel Hill

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2306244392

Cites: 5

Cited by: 5

Related to: 10