Group lasso priors for Bayesian accelerated failure time models with left-truncated and interval-censored data
Year: 2024
Type: article
Abstract: An important task in health research is to characterize time-to-event outcomes such as disease onset or mortality in terms of a potentially high-dimensional set of risk factors. For example, prospective cohort studies of Alzheimer's disease (AD) typically enroll older adults for observation over several decades to assess the long-term impact of genetic and other factors on cognitive decline and mortality. The accelerated failure time model is particularly well-suited to such studies, structuring covariate effects as "horizontal" changes to the survival quantiles that conceptually reflect shifts in the outcome distribution due to lifelong exposures. However, this modeling task is complicated by the enrollment of adults at differing ages, and intermittent follow-up visits leading to interval-censored outcome information. Moreover, genetic and clinical risk factors are not only high-dimensional, but characterized by underlying grouping structures, such as by function or gene location. Such grouped high-dimensional covariates require shrinkage methods that directly acknowledge this structure to facilitate variable selection and estimation. In this paper, we address these considerations directly by proposing a Bayesian accelerated failure time model with a group-structured lasso penalty, designed for left-truncated and interval-censored time-to-event data. We develop an R package with a Markov chain Monte Carlo sampler for estimation. We present a simulation study examining the performance of this method relative to an ordinary lasso penalty and apply the proposed method to identify groups of predictive genetic and clinical risk factors for AD in the Religious Orders Study and Memory and Aging Project prospective cohort studies of AD and dementia.
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
Awards: Methods for High-Dimensional Statistical Inference and Individualized Risk Prediction under Semi-Competing Risks, G3743240706, Pathway discovery, validation and compound identification for Alzheimer's disease, Risk Factors, Pathology, and Clinical Expressions of AD, Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targets, Bayesian multivariate 3D spatial modeling for microbiome image analysis, Multivariate Bayesian variable selection for high-dimensional oral microbiome data, G828200374, G983864884
OpenAlex ID: W4400969482