Are osteoblasts multiple cell types? A new diversity in skeletal stem cells and their derivatives
Year: 2024
Type: article
Abstract: Only in the past decade have skeletal stem cells (SSCs), a cell type displaying formal evidence of stemness and serving as the ultimate origin of mature skeletal cell types such as osteoblasts, been defined. Here, we discuss a pair of recent reports that identify that SSCs do not represent a single cell type, but rather a family of related cells that each have characteristic anatomic locations and distinct functions tailored to the physiology of those sites. The distinct functional properties of these SSCs in turn provide a basis for the diseases of their respective locations. This concept emerges from one report identifying a distinct vertebral skeletal stem cell driving the high rate of breast cancer metastasis to the spine over other skeletal sites and a report identifying 2 SSCs in the calvaria that interact to mediate both physiologic calvarial mineralization and pathologic calvarial suture fusion in craniosynostosis. Despite displaying functional differences, these SSCs are each united by shared features including a shared series of surface markers and parallel differentiation hierarchies. We propose that this diversity at the level of SSCs in turn translates into a similar diversity at the level of mature skeletal cell types, including osteoblasts, with osteoblasts derived from different SSCs each displaying different functional and transcriptional characteristics reflecting their cell of origin. In this model, osteoblasts would represent not a single cell type, but rather a family of related cells each with distinct functions, paralleling the functional diversity in SSCs.
DOI: 10.1093/jbmr/zjae109
Authors: Seoyeon Bok, Jun Sun, Matthew B Greenblatt
Institutions: Weill Cornell Medicine, Hospital for Special Surgery
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: Arthritis National Research Foundation, Children's Tumor Foundation, Ministry of Higher Education and Scientific Research, Marfan Foundation, Pershing Square Foundation, National Research Foundation, National Research Foundation of Korea, Mogam Science Scholarship Foundation, National Institutes of Health, Weill Cornell Medical College, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1153403171, G2319002431, G3859916038, G4558027284, Discovery of a stem cell driving breast cancer spine metastases, G6253470602, G6269216431, A skeletal stem cell orchestrating limb regeneration, A skeletal stem cell basis and novel therapeutic approaches for fracture healing defects in Neurofibromatosis type 1, G8087236155, G9000188198, G9000230829, Discovery of a stem cell governing vertebral physiology
OpenAlex ID: W4400974730