Year: 2024
Type: article
Abstract: Like 'influencers' who achieve fame and power through social media, ceramides are low abundance members of communication platforms that have a mighty impact on their surroundings. Ceramide microdomains form within sphingolipid-laden lipid rafts that confer detergent resistance to cell membranes and serve as important signaling hubs. In cells exposed to excessive amounts of saturated fatty acids (e.g. in obesity), the abundance of ceramide-rich microdomains within these rafts increases, leading to concomitant alterations in cellular metabolism and survival that contribute to cardiometabolic disease. In this mini-review, we discuss the evidence supporting the formation of these ceramide microdomains and describe the spectrum of harmful ceramide-driven metabolic actions under the context of an evolutionary theory. Moreover, we discuss the proximal 'followers' of these ceramide media stars that account for the diverse intracellular actions that allow them to influence obesity-linked disease.
Source: Biochemical Society Transactions
DOI: 10.1042/bst20231395
Institution: University of Utah
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1848409765, G3670720542, G3813662056, G4390647168, G6384266951, Ceramides as Novel Mediators of Tubular Metabolic Dysfunction Driving Kidney Injury, G6616524079, G735756857, G9000090774, G9000303787, Liver-islet and intra-islet cross talk in alpha cell hyperplasia and beta cell regeneration, Targeting Ceramide Signaling: Enhancing Healthy Aging and Combating Tauopathy in Mammals, Interdisciplinary Training Program in Metabolism, The Role of Ceramides in the Pancreatic Beta Cell
OpenAlex ID: W4401174457