Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial
Year: 2024
Type: article
Abstract: This sub-analysis of the ePREDICE trial, investigated the prevalence and determinants of renal complications, specifically glomerular hyperfiltration, albuminuria, and reduced kidney function, in individuals with prediabetes (PD). The cohort consisted of 967 participants from diverse backgrounds across seven countries. The kidney function was evaluated using the MDRD-4 equation, and the influence of various clinical and demographic factors on renal involvement was assessed by multivariable regression models. Additionally, insulinogenic and disposition indices were examined. Overall, the prevalence of renal abnormalities in this PD cohort was 9.2% (n = 89). Key findings included the detection of hyperfiltration in 20 (2%) individuals, albuminuria in 45 (4.7%), and CKD stage G3a in 29 (3%). Hyperfiltration was inversely correlated with age and height, while albuminuria showed a significant direct association with the disposition index (DI). Age and waist circumference were significantly and directly associated with estimated glomerular filtration rate (eGFR). The ePREDICE study highlights critical factors that affect renal involvement in PD individuals, revealing complex interactions among various parameters. These findings further emphasize the necessity for the search of early kidney abnormalities in people with PD especially in those in older age groups and with a large waist circumference.
Source: Scientific Reports
Institutions: Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Universidad Alfonso X el Sabio, Universidad Autónoma de Madrid, Center for Biomedical Research of La Rioja, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, University of Córdoba, University of Helsinki, Instituto de Salud Carlos III, Finnish Institute for Health and Welfare, Escuela Nacional de Sanidad, Instituto de Investigación Sanitaria Fundación Jiménez Díaz
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: Itä-Suomen Yliopisto, Sociedad Española de Nefrología, European Commission, Trinity College Dublin, Institut National de la Santé et de la Recherche Médicale, Heinrich-Heine-Universität Düsseldorf, Karolinska Institutet, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III
Awards: El papel de la inflamación en la prevención de la diabetes tipo 2 y sus complicaciones. La modulación de las vías de señalización inflamatorias como terapia añadida a los nuevos fármacos antidiabéticos., G2609342435, G2620658983, Inflamación como diana terapéutica en las complicaciones de la diabetes tipo 2, G4681458039, Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe, G8086278998
OpenAlex ID: W4405027852