Supplementary Figure 6 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Year: 2024
Type: supplementary-materials
Abstract: MET TKD mutations in NSCLC in cohort #1 and #2. (A) Flowchart of the NSCLC subgroup in cohort #1 (123 MET TKD mutations in 120 unique patients); (B) Prevalence of MET TKD mutations in NSCLC cases according to each dataset in cohort #1; (C) Lollipop plot of the oncogenic / likely oncogenic MET TKD mutations detected in NSCLC cases of cohort #1 (47 oncogenic / likely oncogenic MET TKD mutations in 44 unique patients); (D) Flowchart of the NSCLC subgroup in cohort #2 (590 MET TKD mutations in 586 unique patients); (E) Prevalence of MET TKD mutations in NSCLC cases according to cohort #2 (590 MET TKD mutations in 586 unique patients); (F) Lollipop plot of the oncogenic / likely oncogenic MET TKD mutations detected in NSCLC cases of cohort #2 (129 oncogenic / likely oncogenic MET TKD mutations in 129 unique patients).
Authors: Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K. Lee, Joao V. Alessi, Adriana Barrichello, Victor R. Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M. Gandhi, Dimitris Gazgalis, William W. Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H. Gottlieb, Monica F. Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K. Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S. Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M. Vanderwalde, Patrick C. Ma, Balazs Halmos, Stephen V. Liu, Jianwei Che, Alexa B. Schrock, Alexander Drilon, Pasi A. Jänne, Mark M. Awad
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4401274222