Pachychoroid disease: review and update
Year: 2024
Type: article
Abstract: The pachychoroid disease spectrum is a phenotype characterized by alterations in choroidal vasculature which result in outer retinal and choriocapillaris damage and visual loss. The presence of pachyvessels is one of the key features of the pachychoroid phenotype. Recent imaging studies suggest that pachyvessels may form because of choroidal venous congestion in one or more quadrants. The formation of intervortex anastomosis may function as a compensatory mechanism to dissipate the increased venous pressure, while outflow obstruction has been hypothesized to occur at the site of the vortex vein exiting the sclera. This review aims to summarize recent imaging findings and discuss evolution in the understanding of pathogenesis of the pachychoroid disease spectrum. We have summarized notable treatment trials in central serous chorioretinopathy and polypoidal choroidal vasculopathy and included an update of the current diagnostic and management strategies of the entities that are part of the pachychoroid disease spectrum.
Source: Eye
Institutions: SingHealth, Singapore National Eye Center, SingHealth Duke-NUS Academic Medical Centre, Singapore Eye Research Institute, Duke-NUS Medical School, University of Pittsburgh Medical Center, University of the Ryukyus, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre, Leiden University Medical Center, Amsterdam University Medical Centers, Nune Eye Hospital, Vitreous Retina Macula Consultants of New York, New York University
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,290
OpenAlex ID: W4401304694