Work

A variational model for finger-driven cell diffusion in the extracellular matrix

Year: 2024

Type: article

Abstract: We present a simple chemo-mechanical variational model for a fibrous material that describes (i) the emergence of the anisotropy due to microscopic buckling instabilities (ii) a diffusion in the substrate of the cell phase driven by the new created macroscopic bands characterized by intense compressive deformation. The model is applicable for simulating the spreading of cells within tissues and their interaction with tissue remodeling during mesenchymal migration.

Source: Meccanica

DOI: 10.1007/s11012-024-01835-w

Authors: Antonino Favata, Andrea Rodella, Stefano Vidoli

Institution: Sapienza University of Rome

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,790

Funder: Sapienza Università di Roma