Work

A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm (Adv. Sci. 29/2024)

Year: 2024

Type: article

Abstract: Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi-organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan Yu, and co-workers have developed a drug targeting Heparanase through screening. The drug significantly protects the vascular endothelial glycocalyx and improves survival rates in sepsis mouse models from 0 to 80%, making it a promising candidate for sepsis. More details can be found in article number 2403337.

Source: Advanced Science

DOI: 10.1002/advs.202470175

Authors: Danyang Wang, Kaixuan Wang, Qiutong Liu, Mingyang Liu, Guoqiang Zhang, Ke Feng, Kun Wang, Xianwei Ding, Haomiao Zhu, Song Yang, Yonghui Liu, Tiehai Li, Peng Gong, Manli Wang, Peng George Wang, Hongzhen Jin, Wei Zhao, Fan Yu

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,120

OpenAlex ID: W4401407367

FWCI: 0.262

Cites:

Cited by: 1

Related to: 10