Figure 3 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Year: 2024
Type: other
Abstract: Melanoma tumors that respond to ICIs have a distinct tumor microbiome. A, The relative abundances of the tumor microbiome at the phylum level showed wide intersample variation in the abundances of Proteobacteria (blue) and viruses [Uroviricota (maroon)], without gross differences between nonresponders (NR) and responders (R). B, Differential abundance analysis of taxa found within tumor RNA-seq data. Colored points represent significantly (P value <0.05) enriched taxa with a high (>1.00) fold difference in abundance between responders and nonresponders to ICIs. C, The diversity of the tumor microbiome between responders and nonresponders shows no significant differences. D, The diversity of the microbiome is a poor predictor of outcomes.
Authors: Caroline E. Dravillas, Samuel S. Coleman, Rebecca Hoyd, Griffin Caryotakis, Louis Denko, Carlos H.F. Chan, Michelle L. Churchman, Nicholas Denko, Rebecca D. Dodd, Islam Eljilany, Sheetal Hardikar, Marium Husain, Alexandra P. Ikeguchi, Ning Jin, Qin Ma, Martin D. McCarter, Afaf E.G. Osman, Lary A. Robinson, Eric A. Singer, Gabriel Tinoco, Cornelia M. Ulrich, Yousef Zakharia, Daniel Spakowicz, Ahmad A. Tarhini, Aik Choon Tan
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4401427846