Figure 2 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Year: 2024
Type: other
Abstract: Immune-related gene expression associates with the response to ICIs. A, Gene expression differences between the tumors responsive (right) and nonresponsive (left) to ICI treatment. Significantly different genes after FDR correction are colored and labeled. B and C, GSEA comparing responders vs. the nonresponders using the Hallmark gene set and TIMEx cell types. FDR < 0.1 was used as the cutoff. D, Mann–Whitney comparison of responders and nonresponders for signatures reaching the 0.05 FDR threshold.
Authors: Caroline E. Dravillas, Samuel S. Coleman, Rebecca Hoyd, Griffin Caryotakis, Louis Denko, Carlos H.F. Chan, Michelle L. Churchman, Nicholas Denko, Rebecca D. Dodd, Islam Eljilany, Sheetal Hardikar, Marium Husain, Alexandra P. Ikeguchi, Ning Jin, Qin Ma, Martin D. McCarter, Afaf E.G. Osman, Lary A. Robinson, Eric A. Singer, Gabriel Tinoco, Cornelia M. Ulrich, Yousef Zakharia, Daniel Spakowicz, Ahmad A. Tarhini, Aik Choon Tan
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4401428242