Work

Pyroglutamic acidosis in the setting of Staphylococcus aureus bacteremia treated with flucloxacillin—An uncommon cause of high anion gap metabolic acidosis

Year: 2024

Type: article

Abstract: Pyroglutamic acidosis (PGA) or 5-Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA). This case highlights the importance of systematically approaching HAGMA, and to consider PGA as a differential diagnosis when medications that disrupt the γ-glutamyl cycle such as flucloxacillin and paracetamol are present.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.9243

Authors: Aaron Yee Shuen See, Ashton Zheng‐Boon Lau, Srivathsan Thiruvengadam

Institutions: The University of Western Australia, Royal Perth Hospital

Language: English

Topic: Renal function and acid-base balance

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,730