Work

Isolated Growth Hormone Deficiency

Year: 2024

Type: article

Abstract: Growth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be isolated (IGHD) or associated with other pituitary hormone deficiencies, but most cases are idiopathic. GH stimulation testing is commonly used in the diagnostic workup of GHD, except for some clinical conditions that do not require GH stimulation tests for the diagnosis. Children with GHD receive replacement therapy with daily injections of recombinant human GH (rhGH). RhGH therapy is effective in increasing short-term height gain and adult height in patients with GHD. The safety of long term GH therapy has been confirmed in many large international studies. Recently, long-acting weekly GH formulations have been introduced, showing good efficacy and safety profiles.

Source: Endocrines

DOI: 10.3390/endocrines5030025

Authors: Anastasia Ibba, Chiara Guzzetti, Lavinia Sanfilippo, Sandro Loche

Institutions: Ospedale Microcitemico, University of Cagliari, Azienda Ospedaliero-Universitaria Cagliari, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,137